David J Lederer Selected Research

Therapeutics

1/2022	Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial.
1/2022	Effect of positive airway pressure therapy of obstructive sleep apnea on circulating Angiopoietin-2.
12/2021	Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.
1/2021	Summary for Clinicians: Clinical Practice Guideline on Home Oxygen Therapy for Adults with Chronic Lung Disease.
11/2020	Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline.
1/2020	Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial.
11/2019	Diagnostic Likelihood Thresholds That Define a Working Diagnosis of Idiopathic Pulmonary Fibrosis.
11/2019	Modelling Forced Vital Capacity in Idiopathic Pulmonary Fibrosis: Optimising Trial Design.
12/2018	Optimizing Home Oxygen Therapy. An Official American Thoracic Society Workshop Report.
1/2017	Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis.

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David J Lederer Research Topics

Disease

30	Idiopathic Pulmonary Fibrosis 01/2021 - 04/2009
25	Primary Graft Dysfunction 11/2021 - 07/2009
20	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 11/2009
13	Frailty 01/2023 - 02/2012
12	Asthma (Bronchial Asthma) 01/2024 - 12/2021
12	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 04/2006
12	Lung Diseases (Lung Disease) 01/2021 - 04/2006
12	Pulmonary Arterial Hypertension 01/2018 - 01/2006
9	Inflammation (Inflammations) 12/2023 - 03/2010
9	Atherosclerosis 01/2022 - 11/2016
9	Fibrosis (Cirrhosis) 01/2020 - 01/2012
9	Disease Progression 01/2020 - 05/2013
6	Obesity 11/2021 - 11/2009
6	Pulmonary Hypertension 01/2019 - 02/2008
5	Acute Lung Injury 11/2021 - 08/2011
5	Emphysema 01/2019 - 06/2007
3	COVID-19 01/2022 - 10/2021
3	Ischemia 11/2021 - 03/2008
3	Hypoxia (Hypoxemia) 11/2020 - 12/2018
3	Critical Illness (Critically Ill) 11/2019 - 10/2013
3	Respiratory Insufficiency (Respiratory Failure) 11/2019 - 03/2016
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 03/2011
3	Lung Injury 01/2018 - 09/2012
3	Cystic Fibrosis (Mucoviscidosis) 01/2017 - 11/2009
2	Sarcopenia 01/2023 - 02/2012
2	Reperfusion Injury 11/2021 - 03/2008
2	Pneumonia (Pneumonitis) 11/2021 - 01/2017
2	Cough 01/2020 - 01/2017
2	Pulmonary Atelectasis 01/2020 - 11/2016
2	Clinical Deterioration 01/2019 - 03/2016
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2018 - 10/2005
2	Hyperoxia 01/2018 - 04/2016
2	Chronic Disease (Chronic Diseases) 08/2017 - 07/2013
2	Overweight 01/2017 - 03/2013
2	Pain (Aches) 08/2016 - 03/2015
2	Dyspnea (Shortness of Breath) 01/2016 - 06/2007
2	Agammaglobulinemia (Hypogammaglobulinemia) 01/2014 - 04/2006
2	Pulmonary Edema 08/2013 - 01/2011
2	Hemorrhage 06/2011 - 10/2005
1	Body Weight (Weight, Body) 01/2024
1	Malnutrition (Nutritional Deficiencies) 01/2023
1	Ventilator-Induced Lung Injury 01/2022
1	Obstructive Sleep Apnea 01/2022
1	Coinfection 10/2021
1	Connective Tissue Diseases (Connective Tissue Disease) 01/2021
1	Vascular Diseases (Vascular Disease) 11/2020

Drug/Important Bio-Agent (IBA)

22	Biomarkers (Surrogate Marker)IBA 01/2024 - 09/2012
21	Prostaglandins DIBA 11/2021 - 07/2009
12	dupilumabIBA 01/2024 - 12/2021
12	pirfenidoneIBA 01/2020 - 05/2014
7	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2024 - 12/2021
7	Oxygen (Dioxygen)IBA 12/2021 - 10/2013
6	Monoclonal AntibodiesIBA 12/2023 - 01/2020
6	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2023 - 01/2006
5	InterleukinsIBA 12/2023 - 01/2022
4	Interleukin-6 (Interleukin 6)IBA 10/2021 - 03/2015
4	Carbon MonoxideIBA 01/2020 - 01/2018
4	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2016 - 03/2011
4	Simvastatin (Zocor)FDA LinkGeneric 01/2016 - 03/2011
3	Bronchodilator Agents (Bronchodilators)IBA 11/2023 - 01/2023
3	AdipokinesIBA 11/2020 - 11/2011
3	LeptinIBA 01/2020 - 11/2011
2	Interleukin-4 (Interleukin 4)IBA 12/2023 - 01/2023
2	Interleukin-13IBA 12/2023 - 10/2023
2	Immunoglobulin E (IgE)IBA 10/2023 - 01/2023
2	CytokinesIBA 01/2023 - 01/2021
2	Hemoglobins (Hemoglobin)IBA 01/2023 - 01/2018
2	Angiopoietin-2IBA 01/2022 - 01/2012
2	sarilumabIBA 01/2022 - 12/2021
2	AdiponectinIBA 01/2020 - 11/2011
2	simtuzumabIBA 01/2020 - 01/2017
2	ResistinIBA 01/2020 - 11/2011
2	Peptides (Polypeptides)IBA 10/2019 - 12/2016
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 03/2010
2	CollagenIBA 01/2018 - 01/2017
2	Matrix Metalloproteinase 7 (Matrilysin)IBA 11/2017 - 11/2016
2	CreatinineIBA 10/2017 - 06/2008
2	SmokeIBA 10/2017 - 04/2016
2	Receptor for Advanced Glycation End ProductsIBA 05/2017 - 11/2009
2	Serum AlbuminIBA 07/2013 - 04/2009
1	Chemokine CCL26IBA 10/2023
1	Chemokine CCL17IBA 10/2023
1	Interleukin-18 (Interleukin 18)IBA 11/2021
1	Immunologic Factors (Immunomodulators)IBA 10/2021
1	Hormones (Hormone)IBA 01/2021
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	Docosahexaenoic AcidsIBA 01/2021

Therapy/Procedure

49	Lung Transplantation 01/2023 - 10/2005
15	Therapeutics 01/2022 - 10/2005
9	Transplantation 01/2019 - 02/2008
4	Artificial Respiration (Mechanical Ventilation) 01/2022 - 10/2013
4	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/2017 - 11/2011
3	Contraindications 01/2017 - 11/2009
2	Organ Transplantation 01/2019 - 12/2015
2	Critical Care (Surgical Intensive Care) 08/2017 - 01/2016
2	Palliative Care (Palliative Therapy) 06/2017 - 10/2013
2	Pneumonectomy (Lung Volume Reduction) 09/2007 - 06/2007
1	Subcutaneous Injections 12/2021
1	Activities of Daily Living (ADL) 01/2021